Orthogonal modification of polymer chain-ends via sequential nitrile oxide–alkyne and azide–alkyne Huisgen cycloadditions
نویسندگان
چکیده
منابع مشابه
Spatioselective Modification of Bicompartmental Polymer Particles and Fibers via Huisgen 1,3-Dipolar Cycloaddition
Precise nanoand microscale control of the architecture of biodegradable biomaterials is desirable for several biotechnological applications such as drug delivery, diagnostics, and medical imaging. Herein, we combine electrohydrodynamic co-jetting and highly specific surface modification (via Huisgen 1,3-dipolar cycloaddition) to prepare particles and fibers with spatioselective surface modifica...
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We report here the synthesis of a novel electroactive polyolefin and demonstrate through a combination of SEC-MALS and DLS how this type of functional polymer can be folded in a controlled fashion from an expanded coil to a tightly wound globule using sequentially activated noncovalent and covalent intra-chain interactions.
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The dipolar cycloadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.
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An efficient, catalyst free, 1,3-dipolar cycloaddition strategy to conjugate nucleosides and nucleotides with isoxazoles under atmospheric conditions and in an aqueous environment is reported. The protocol involves chloramine-T as a practical reagent to induce in situ nitrile oxide formation and the alkyne partner is attached to the sugar residue or the nucleobase. The reactions are regiospecif...
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ژورنال
عنوان ژورنال: Polym. Chem.
سال: 2011
ISSN: 1759-9954,1759-9962
DOI: 10.1039/c0py00236d